Men Against Cancer (MAC)

Prostate and Testicular Support Group in Partnership with the Irish Cancer Society

A Member of Europa Uomo the European Prostate Cancer Coalition

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Mike


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Joined Sep 1 2012
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General Info

MALE
78 years old
Bornacoola, Leitrim
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Men Against Cancer

About Me

I am 69, and have had PCa stage 3 Gleason 8 for about 5 years. My PSA is holding since my treatment at 0.1 approx. Treatment consisted of ADT & Radiation. I do not really expect a "cure" as such as once it had metastasised the cat was out of the bag. So all I hope for really is a very long remission, as there are really no worthwhile new treatments for CRPC on the horizon.Yes, I know about Abiraterone and have ben following that story since it was first mentioned about 5 years ago. However, I am of the opinion that an extension to life of perhaps 5 months is just delaying the inevitable and perhaps protracting the sense of impending loss experienced by one's family. All I would wish for would be a painfree passing when the time comes, as scientists and doctors describe the end game as "excruciatingly painful". However, I think that depends on where one lives at the time as I would think that a good hospice in the area would ease one's difficulty greatly. No chance of that where I am living at present.

I live in Leitrim, where there is no support network, yet on average there must be hundreds of men with the disease living in this area. A peculiar thing of some interest is that from the age of 33, I had a PSA test every year without fail! I wish all you PCa patients well, remember that those with early diagnosis and treatment, it is very curable and people go on to lead full lives in the majority of cases.

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1 Comment

Reply John Dowling
1:04 PM on September 29, 2012 
Mike
Your story is very moving and poignant. I was diagnosed in May 2002 with a PSA of 23 and a Gleason score of 6 (3+3) and perineural invasion. Treatment was ADT for 8 months and 3D conformal external beam radiation and I ceased ADT after radiotherapy. My PSA nadir was 0.01 ng/ml and it remained at that for some time. In late 2006 my PSA started to rise and by late 2007 it had reached 5 ng/ml and I commenced ADT on a long term basis. My PSA returned to its former levels of virtually undetectable.

I respect your view on the prospect of treatment should your current ADT become refractory but I think you may be selling Abiraterone and other preparations a bit short. My understanding is that the revised results of the phase III trial (see http://advancedprostatecancer.net/?cat=85 )indicates that the median life extension time was 15.8 months for Abiraterone compared with 11.2 months for those who took only the placebo and prednisone. The article for which I have provided the link above also discusses other preparations in the pipeline. I think, therefore, that your consideration of treatment or not should take into account that the extension of newer treatments is considerable. Given that half of those taking the preparation survived for more than 15.8 months and the median may have been adversely affected by the fact that some of these men may have had serious co-morbidities. If you are relatively fit you may have a lot more potential for a longer life than you appear to think - see Prof Fitzpatrick's talk to the MAC AGM last May. The problem in Ireland at the moment is that both Cabazitaxel and Abiraterone have not been recommended for reimbursement due to the cost of the preparations. Hopefully there will be negotiations between the Health Service and the drug companies. Prof Fitzpatrick also mentioned MD3100 which has now called Enzalutamide which has not yet been submitted for approval here in Ireland.
If you would like to talk on the phone or exchange emails please feel free to contact me at [email protected]
Regards
John Dowling
Chairman
Men Against Cancer